Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis
نویسندگان
چکیده
منابع مشابه
Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis
Delocalized lipophilic cations (DLCs) selectively accumulate in cancer cell mitochondria and have long been explored for therapeutic applications. Although targeted effects to cancer cells are demonstrated in vitro, non-specific toxicities in vivo have hampered clinical development. Identifying the molecular mechanisms of action and enhancing selectivity are thus necessary next steps to improve...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2017
ISSN: 2041-4889
DOI: 10.1038/cddis.2017.19